At the same time, previous studies have found the association between septicemia and high serum CysC levels, and the association trend between Acute Physiology and Chronic Health Evaluation II(APACHE II) and cystatin C [28], which may represent direct and indirect inflammation, as some authors have suggested, CysC may reflect the pathogenic state other than GFR [29]. This evidence concerns the gene CST3 and Sepsis.