IRF4 has been proved to be involved in the onset and progression of multiple diseases, such as cancers and stroke.10, 11, 12, 13 For instance, IRF4 mediated by the hsa_circ_0000301/hsa-miR-1228-3p axis may be involved in the occurrence and development of cervical cancer.10 This evidence concerns the gene IRF4 and cervical cancer.