Altogether, it might be reasonable to conclude that has_circ_0001944 may act as a promoter in CRC by sponging miR-548b-5p and then releasing WNT2. This finding expands the understanding of the circRNA/miRNA regulatory network in CRC and suggests the therapeutic potential of silencing has_circ_0001944 in CRC. This evidence concerns the gene WNT2 and colorectal carcinoma.