On the 3rd month and 5th month posttransplant, patients with PvB19 related PRCA had significantly lower total lymphocytes (P = 0.018 and 0.002), CD3 + (P = 0.022 and 0.003), CD4+ (P = 0.045 and 0.020), and CD8+ (P = 0.033 and 0.006) lymphocyte counts (Fig. 1A and Table 3). Here, CD4 is linked to pure red-cell aplasia.