Inflammatory responses, oxidative stress, immune system dysfunction, and epigenetic changes are considered to be involved in the pathogenesis of neuropathic pain.39, 40, 41, 42, 43, 44 SIRT1 has been reported to play a key role in neuropathic pain caused by peripheral nerve injury, SCI, and chemotherapy‐induced peripheral neuropathy.45, 46, 47, 48, 49. The gene discussed is SIRT1; the disease is peripheral nerve injury.