Within this study, we show that in individuals who do not develop severe COVID‐19, age is associated with a more robust polyfunctional Th1‐CD4 T‐cell response to SARS‐CoV‐2 peptides, indicating a protective role for SARS‐CoV‐2‐directed Th1‐CD4 T‐cell responses with increasing age. This evidence concerns the gene CD4 and COVID-19.