In the TCx, ACE-1 activity was significantly increased in AD (unpaired t test; p = .028; Figure 4K) and was significantly elevated in BS III–IV compared to BS 0–II (Tukey’s; p = .01; Figure 4L) but no significant difference was observed between BS 0–II and V–VI (Tukey’s; p = .35) or between III–IV and V–VI (Tukey’s; p = .26; Figure 4L). The gene discussed is ACE; the disease is Alzheimer disease.