ACE-1 activity was unchanged in the FCx of AD compared to controls (unpaired t test; p = .17; Figure 4I) although a trend towards higher activity was observed in BS III–IV and BS V–VI compared to BS 0–II (Tukey’s; BS 0–II vs BS III–IV p = .09, BS 0–II vs BS V–VI p = .10; Figure 4J). Here, ACE is linked to Alzheimer disease.