Similarly, in the TCx, no significant difference in ACE-1 level was seen between AD and age-matched controls (unpaired t test; p = .48; Figure 4C) or with Braak tangle stage (Tukey’s; BS 0–II vs III–IV p = .86, BS III–IV vs V–VI p = .99; Figure 4D). Here, ACE is linked to Alzheimer disease.