IL6 and malaria: Subgroup analysis of age groups showed higher mean IL-6 levels in people with uncomplicated malaria than in controls among studies that enrolled patients of all age groups (P < 0.001, WMD = 43.47 pg/mL, 95% CI = 27.63 − 59.31 pg/mL, I2 = 95.7%, two studies) or adults only (P < 0.001, WMD = 22.97 pg/mL, 95% CI = 12.03–33.9 pg/mL, I2 = 99.9%, eight studies).