IL6 and malaria: Subgroup analysis of age groups showed higher mean IL-6 levels in those with severe malaria than in those with non-severe malaria among studies that enrolled patients of all age groups (P < 0.001, WMD = 133.57 pg/mL, 95% CI = 67.77−199.38 pg/mL, I2 = 95.6%, two studies).