Eligibility included gBRCAm carriers who had residual disease after at least six cycles of neoadjuvant chemotherapy (95% of whom received anthracycline/alkylator/taxane-based chemotherapy), with a higher tumor burden required for those with hormone receptor-positive disease (i.e., clinical stage, pathologic stage, estrogen receptor and tumor grade (CSP + EG) score ≥ 3). Here, ESR1 is linked to neoplasm.