Distribution of gene mutations among risk group of MDS showed significant (p = 0.008) association of TP53 gene mutation with high risk IPSS-R group (IPSS R score > 3.5) whereas SF3B1 was associated with low risk (IPSS R score ≤ 3.5) MDS patients (p = 0.021). The gene discussed is SF3B1; the disease is myelodysplastic syndrome.