All NPM1 mutated patients in our study are females (100% vs. 43.9%, p = 0.04), NPM1-mutated MDS patients were younger (median age, 48 vs. 56 years, p < 0.67), had median BM blast percentage at diagnosis (5.5% vs. 3%, p < 0.928), and had a 100% frequency of normal karyotype (100% vs. 58.8%, p < 0.149) compared with NPM1 wild-type patients. The gene discussed is NPM1; the disease is myelodysplastic syndrome.