Although distribution of gene mutations among age group revealed that older MDS patients had high incidence of SF3B1 (28.6% vs. 21.8%), U2AF1 (19.6% vs. 9.1%), ASXL1 (12.5% vs. 7.3%), TET2 (14.3% vs. 3.6%) and DNMT3A (7.1% vs. 1.8%) mutations, no statistical difference was observed when compared with the younger patients (p > 0.05) (Table 2). The gene discussed is U2AF1; the disease is myelodysplastic syndrome.