APOE and Alzheimer disease: Analyses conducted with FUMA, based on the main results from the European circulating t-tau meta-analysis, identified significantly differentially expressed genes in brain cerebellar hemisphere and brain cerebellum (Supplementary Fig. 28) and enrichment of genes in gene sets reported by GWAS of neurological diseases or traits including Parkinson Disease (PD), craniofacial microsomia, intracranial volume, cognitive function, subcortical brain region volumes, and AD in APOE E4- carriers, as well as risk factors such as body mass index (Supplementary Fig. 29).