CFTR and cystic fibrosis: That rs7512462 was not shown to be a strong modifier of CF lung disease5,31 in the absence of treatment with CFTR correctors but is associated with lung function in a non-CF population study9,33 is consistent with functional studies, where differential SLC26A9 interaction with wild-type CFTR and with Phe508del-CFTR in human bronchial epithelia (HBE) has been reported25,31.