CF GWAS of early-onset CF pancreatic and intestinal phenotypes were CFTR genotype independent1–3,7; that is, those homozygous for Phe508del still demonstrated genome-wide significance with benefit from the C allele of rs7512462, a marker of SLC26A9 gene expression in CF phenotypes that show pre-natal onset (for example, meconium ileus). This evidence concerns the gene SLC26A9 and intestinal obstruction in the newborn due to guanylate cyclase 2C deficiency.