CF GWAS of early-onset CF pancreatic and intestinal phenotypes were CFTR genotype independent1–3,7; that is, those homozygous for Phe508del still demonstrated genome-wide significance with benefit from the C allele of rs7512462, a marker of SLC26A9 gene expression in CF phenotypes that show pre-natal onset (for example, meconium ileus). The gene discussed is CFTR; the disease is cystic fibrosis.