From our results of RNA-seq and RT-qPCR, Western Blot and ELISA, we can make reasonable assumptions that BLM activates GSDMD and promotes the upregulation and secretion of IL-1β, while genetic ablation of GSDMD reduces the expression of IL-1β in BLM-induced scleroderma mice. This evidence concerns the gene IL1B and scleroderma.