To elucidate the clinical significance of MLL and MMP2 expression, we investigated the co-expression relationships between KMT2A (encoding MLL) and MMP2 genes using available microarray-based gene expression profiling of AML patients, and also examined the association between MMP2 expression and patient survival with HU treatment using the TCGA AML dataset. Here, MMP2 is linked to acute myeloid leukemia.