Not only that, an MLL-r AML cell line SHI1 (MLL-AF6), in which MMP2 was highly expressed, displayed tolerance to HU compared with low MMP2 expressed MOLM13 (MLL-AF9) and MV411 (MLL-AF4) cell lines (Fig. 3g). The gene discussed is MMP2; the disease is acute myeloid leukemia.