An additional known member of the dispanin/CD225 family is the neuron specific PRoline-Rich Transmembrane protein 2 (PRRT2, B subfamily) that is involved in neurotransmitter vesicles regulation and has been genetically linked to benign familial infantile seizures and to paroxysmal kinesigenic dyskinesia (PKD), the most common type of paroxysmal movement disorder (5). Here, PRRT2 is linked to benign familial infantile epilepsy.