GFPT2 and non-small cell lung carcinoma: To examine the status of the HBP (Fig 1A) in human NSCLC, we assessed the expression level of its rate-limiting enzyme paralogs GFPT1 and GFPT2 using publicly available gene expression data of paired tumor-normal samples (LUAD n = 58; LUSC n = 52) from The Cancer Genome Atlas (TCGA).