For example, a frequent mutation in gliomas, isocitrate dehydrogenase (IDH) 1 and 2 results in inhibition of all 2OG-dependent dioxygenases, including TET protein’s ability to catalyze 5mC to 5hmC (Yen et al., 2010; Xu et al., 2011; Huang and Rao, 2014). Here, IDH3A is linked to central nervous system cancer.