This retention, together with the absence of CD9 in HF-EVs, the slightly increase of CD81 in the sEVs population secreted by HF-MSCs, and the retention of LAMP1 in HF-MSCs, suggest that both cell lines had a different balance of endosomal/ectosomal mechanism of EVs biogenesis [55]. This evidence concerns the gene LAMP1 and hydrops fetalis.