Meanwhile, increased PIK3R2 expression predicted better OS for CESC (HR = 0.50, P = 0.0038), TGCT (HR = 0, P = 0.0095) and better RFS for CESC (HR = 0.4, P = 0.02) and PCPG (HR = 0, P = 0.032) (Fig. 2F), but we did not observe that PIK3R1 significantly influenced the prognosis of these three cancers. Here, PIK3R2 is linked to cancer.