Specially, we identified highly expression of PIK3R1 as favorable prognostic factors in ESCA (OS: HR = 0.41, P = 0.012) and UCEC (OS: HR = 0.6, P = 0.023) and as detrimental factors in KIRP (RFS: HR = 2.92, P = 0.0036) and PAAD (RFS: HR = 3.53, P = 0.0029) (Fig. 2C), while we failed to obtain a correlation between PIK3R2 expression and prognosis in these cancers. Here, PIK3R1 is linked to cancer.