Another report on 98 patients with bladder cancer showed that mutations in DNA repair genes (CHEK2, ERCC5, GEN1, MLH1, PALB2, RAD50, RAD51B and RECQL4) are associated with an unfavorable cancer prognosis and 22% of patients had a mutation [30]. The gene discussed is PALB2; the disease is urinary bladder carcinoma.