The results of our unselected cohort 1028 bladder, 688 kidney cancer cases and two groups of controls 4000 and 2791 revealed no statistical significant difference, indicating that three mutations of BRCA1 gene (5328 insC, C61G, 4153 delA) and one mutation of gene BRCA2 (C5972T) do not seem to play a role in bladder or kidney cancer development. Here, BRCA1 is linked to kidney cancer.