In DLBCL cells, TBK1 mediates the activation of canonical NF-κB signaling via phosphorylation of p65/RelA on Ser536, which promotes the production of IL-10, CCL3, and CCL4; these cytokines promote tumorigenesis by stimulating STAT3 activation. The gene discussed is TBK1; the disease is diffuse large B-cell lymphoma.