TBK1 and neurodegenerative disease: Mutation-associated haploinsufficiency of the TBK1 gene has been implicated as a causal event in several types of inflammatory/neurodegenerative diseases, including amyotrophic lateral sclerosis, frontotemporal dementia, Alzheimer’s disease/tauopathies, childhood herpes simplex virus-1 encephalitis (HSE), progressive supranuclear palsy-like syndrome, and a singular case of Parkinsonian-pyramidal syndrome [20, 22, 27, 30–35].