In the KRasLSL-G12D/+Cdkn2aLox/LoxPtf1aCre/+ PDA mouse model, Tbk1 deletion in the malignant cells resulted in reduced tumor load and reduced metastatic behavior, indicating that Tbk1 activity contributes directly to the aggressive properties of pancreatic cancers. This evidence concerns the gene TBK1 and pancreatic neoplasm.