Germline Tbk1-knockout (Tbk1−/−) mice of a C57BL/6 background die of liver failure [161], whereas Tbk1−/− mice of 129S5 background (Tbk1Δ/Δ) are viable but highly sensitive to LPS-induced inflammation and display neurodegenerative phenotypes [24, 187] . The gene discussed is TBK1; the disease is liver failure.