IFNG and neoplasm: Taken together, these results on STUB1 increase our understanding of the context-dependent effects of IFNγ signaling, in particular that enhanced IFNγ signaling, through STUB1 inactivation, can improve response to anti-PD-1 in heterogeneous tumors, in which also wildtype tumor cells are present, but not homogenous STUB1-deficient tumors.