First, using publicly available single cell RNA sequencing data from patient tumors37–39, we asked whether tumor-intrinsic expression of the IFNγ-R complex components (comprising IFNγ-R1, IFNγ-R2, JAK1, JAK2 and STAT1), whether as a whole complex or each component independently, correlates with an IFNγ response signature in malignant cells (Fig. 1a and Supplementary Fig. 1a). Here, JAK1 is linked to neoplasm.