EZH2 and neoplasm: To investigate the effect of EZH2 inhibition in a DMG in vivo tumor model, we established mutant H3.3K27M tumors in the ABC KO mice, and treated intraperitoneal (i.p) with Tazemetostat (EPZ-6438, SelleckChem, 400 mg/kg b.w.)for 7 days to enable drug penetration through the blood–brain barrier [31, 50].