SETDB1 and neoplasm: Interestingly, knockdown of PELP1 in SETDB1 overexpression (MCF7-PELP1KD + SETDB1) xenografts resulted in significantly reduced tumor growth compared to MCF7-SETDB1 xenografts, suggesting that PELP1 KD effectively reduces SETDB1 mediated tumor progression (Fig. 7A).