By contrast to TET1 wild-type patients, TET1-mutated patients in the ICI-treated cohort were found to have a significantly increased mutation number of DDR pathways, including nucleotide excision repair (NER), Fanconi anemia (FA), homologous recombination (HR), and nonhomologous end joining (NHEJ). This evidence concerns the gene TET1 and Fanconi anemia.