As diverse pyroptotic, necrotic, and apoptotic cell death inducers have been demonstrated to induce p53-dependent increases in Ninj1 expression in macrophages [22], we next analyzed the response of NSCLC cell lines carrying WT or mutant/null TP53 to pyroptotic (i.e., hypoxia, paclitaxel, and cisplatin) [39, 40], necrotic (i.e., hypoxia, glucose deprivation, paclitaxel, and cisplatin) [41–44], and apoptotic (i.e., hypoxia, serum or glucose deprivation, paclitaxel, and cisplatin) stimuli [41, 45]. Here, TP53 is linked to non-small cell lung carcinoma.