PODXL and neoplasm: Indeed, upon treatment with the protein synthesis inhibitor cycloheximide [53], the half-life of β-catenin was significantly increased in H1299-Ninj1 cells and was decreased in H460-shNinj1 cells and PDX-derived primary tumor cells transfected with Ninj1 siRNAs (PDX-siNinj1) compared to that in the corresponding control cells (Fig. 6b, S6b, S6c).