HLA-G and hereditary clear cell renal cell carcinoma: In renal cell carcinomas, the CD105+ CSCs-derived extracellular vesicles (EVs) carry a soluble type of MHC-I, HLA-G (sHLA-G), which act as a ligand for immunoglobulin-like transcript (ILT) inhibitory receptors and thus impair monocyte differentiation into mature DCs through IL-6–STAT3 signaling pathway [14, 15].