They were related to environmental information processing (PI3K-Akt signaling pathway), human diseases (Pathways in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, Human papillomavirus infection, Amoebiasis, Pertussis, Yersinia infection, Small cell lung cancer, AGE-RAGE signaling pathway in diabetic complications), cellular processes (Relaxin signaling pathway), organismal systems (Th17 cell differentiation, Th1, and Th2 cell differentiation, Complement and coagulation cascades, Protein digestion and absorption, Hematopoietic cell lineage). The gene discussed is AKT1; the disease is amebiasis.