FGFR3 and nasopharyngeal carcinoma: There are also scattered FGFR mutations and activating FGFR3-transforming acidic coiled-coil containing protein 3 (TACC3) fusions among NPC tumors, suggesting an evolutionary pressure to activate the FGF/FGFR signaling pathway (11, 57); such tumors may similarly be responsive in an inhibitory strategy.