Conceivably, systemic changes in redox signalling with exercise, could activate redox-sensitive antioxidant genes within the tumour (possibly through kelch-like ECH-associated protein 1-nuclear factor (erythroid-derived 2)-like 2 (Keap-Nrf2) and PGC-1α) to attenuate oxidative damage [53]. This evidence concerns the gene PPARGC1A and neoplasm.