Although it has been reported that oxidative stress in osteoblasts plays a significant role in the pathogenesis of osteoporosis (Almeida et al., 2007; Rached et al., 2010), with SOD2 being important for removal of excessive ROS (Younus, 2018), the exact molecular and functional consequences of mtROS accumulation in osteoblastic cells are still not completely understood. Here, SOD2 is linked to osteoporosis.