SOD2 and osteoporosis: Although decreased SOD2 activity and subsequent disbalance in mtROS have previously been described in aging mesenchymal progenitor cells (Almeida and O'Brien, 2013; Chen et al., 2019; Stolzing et al., 2008; Stolzing and Scutt, 2006), the consequences on bone integrity and development of osteoporosis have not been addressed before.