All these data suggest that ALDH2 downregulated ABCA1 expression and decreased cholesterol efflux from LKO liver tissues through attenuating poly(ADP-ribosyl)ation of LXRα, which manifested as lower levels of HDL in the circulation but increased hepatic steatosis in ALKO compared with LKO mice (Figure 4D and Figure 1, D–F). This evidence concerns the gene NR1H3 and Hepatic steatosis.