ALDH2 and Wilson disease: In the WD group, pathway enrichment analysis demonstrated that significantly differential metabolites belonged to 16 pathways, and the top 3 pathways were galactose metabolism, fructose and mannose metabolism, and purine metabolism (Supplemental Figure 3, A and B), suggesting a potential mechanistic link between the purine metabolism pathway and ALDH2-mediated ABCA1 expression and HDL biogenesis in the mouse liver with WD feeding.