NR1H3 and fatty liver disease: All these data suggest that ALDH2 downregulated ABCA1 expression and decreased cholesterol efflux from LKO liver tissues through attenuating poly(ADP-ribosyl)ation of LXRα, which manifested as lower levels of HDL in the circulation but increased hepatic steatosis in ALKO compared with LKO mice (Figure 4D and Figure 1, D–F).