HMGCR and Hepatic steatosis: Interestingly, CD feeding did not significantly change the HDL-C levels and body weights between AKO and WT mice but significantly promoted hepatic steatosis in AKO mice (Supplemental Figure 1, A–C; supplemental material available online with this article; https://doi.org/10.1172/jci.insight.155869DS1), presumably through regulating de novo cholesterol biosynthesis and HMGCR protein stability (33) (see complete unedited blots in the supplemental material).