KLF5 and colon adenocarcinoma: In comparison with healthy individual and colon adenocarcinoma samples, samples of patients with active UC had a substantial decrease in KLF5 level in colonic epithelial cells (Figure 1B); moderate colitis had decreased KLF5 expression compared with healthy individuals, but this reduction was more pronounced in areas of severe colitis than moderate colitis or healthy individuals (Figure 1C).