STAT3 and colonic neoplasm: To further verify mislocalization of p-STAT3, a human adenocarcinoma colon cancer cell line, Caco-2BBE, with doxycycline-inducible (DOX-inducible) nonsilencing shRNA (C2BBECtrl) or DOX-inducible knockdown of KLF5 (C2BBEΔIND) was utilized (24).