SIRT3 and Parkinson disease: We have shown previously that the gene therapy, AAV.SIRT3-myc [recombinant adeno-associated virus serotype over-expressing myc-tagged Sirtuin 3] is both neurorestorative and neuroprotective in rat models of Parkinson’s disease (PD; Gleave et al., 2017; Gleave et al., 2018).