It has been shown that the TLR4/myeloid differentiation primary response 88 (MyD88)/nuclear factor (NF‐kB) signalling pathway mediates neuroinflammation in CNS diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), subarachnoid haemorrhage (SAM) and vascular dementia.10, 11, 12. The gene discussed is TLR4; the disease is Parkinson disease.