Moreover, the observation that Lphn3/FLRT3-mediated signaling through G13 during intercellular adhesion was impacted by all ADHD-related missense variants while Teneurin4-mediated cell-cell contacts were affected by a subset of these variants, suggests a differential contribution of cytoskeletal signaling/anchoring processes to ligand-specific molecular events, thus supporting the previous identification of FLRT3 as an ADHD-associated risk gene [46]. Here, FLRT3 is linked to attention deficit-hyperactivity disorder.