Activation of SAPK/JNK, p44/p42MAPK and p38MAPK, known potential mediators of DUSP1 signalling, was investigated through western blotting in U87 GBM cells and G179 GSCs treated with CP-673451 and BCI compared to CP-673451 treatment alone [32]. The gene discussed is DUSP1; the disease is glioblastoma.