Lastly, further experimentation into potential resistance mechanisms of CP-673451 could be a very interesting avenue to explore in future studies, as it has already been reported that GBM cells can recruit different compensatory pathways, including ERBB3, IGF1R, TGFBR2 and IGF1R-mediated signalling, in order to induce resistance to PDGF-R inhibition [50, 51]. The gene discussed is ERBB3; the disease is glioblastoma.