U87 GBM cells upon treatment with CP-673451 significantly activated Hallmark KRAS signalling (Enrichment Score = 0.40, p-value = 0.003) and Hallmark NF-κB signalling (Enrichment Score = 0.45, p-value = 0.00019) in comparison to U87 GBM cells treated with DMSO (Fig. 6D). The gene discussed is NFKB1; the disease is glioblastoma.