In this study, we found that 238 DEGs partially overlapped between different inflammatory skin diseases and identified 12 candidate biomarkers that overlapped, namely, ACR, APOE, ASIP, CRISP1, DKK1, IL12B, IL9, MANF, MDK, NRTN, PCSK5, and VEGFC. Here, PCSK5 is linked to inflammatory skin disease.