In this study, we found that 238 DEGs partially overlapped between different inflammatory skin diseases and identified 12 candidate biomarkers that overlapped, namely, ACR, APOE, ASIP, CRISP1, DKK1, IL12B, IL9, MANF, MDK, NRTN, PCSK5, and VEGFC. The gene discussed is APOE; the disease is inflammatory skin disease.