NF1 and neoplasm: Aberrant induction of Ras/MEK/ERK signaling is mandatory for neoplastic growth in Neurofibromatosis type 1 (NF1) [7], a tumor-predisposing genetic disorder caused by loss of function mutations of the NF1 gene encoding the Ras-GAP (GTPase-activating protein) neurofibromin [8].