Aberrant induction of Ras/MEK/ERK signaling is mandatory for neoplastic growth in Neurofibromatosis type 1 (NF1) [7], a tumor-predisposing genetic disorder caused by loss of function mutations of the NF1 gene encoding the Ras-GAP (GTPase-activating protein) neurofibromin [8]. This evidence concerns the gene MAP2K7 and neoplasm.