For example, prior research has shown that the obesity-prone allele of FTO SNP (e.g., A allele of rs9939609) was associated with a higher likelihood of becoming depressive, independent of BMI49, likely reflecting a shared genetic influence of FTO gene on phenotypes (i.e., pleiotropy on depression and BMI). This evidence concerns the gene FTO and obesity due to melanocortin 4 receptor deficiency.