SORCS3 and central nervous system cancer: Western blot analysis showed that in SorCS3-overexpressing glioma cells, the protein expression of the epithelial marker E-cadherin was upregulated, while the expression of the mesenchymal marker vimentin, as well as the transcriptional repressors Snail and PCNA, was markedly decreased (Fig. 2J–L, Western blots were given in Original Data of Supplemental Material).