SORCS3 and central nervous system cancer: To explore the potential roles of SorCS3 in glioma, we analysed RNA sequencing results from TCGA database and found that the mRNA level of SorCS3 was decreased in glioma, and we demonstrated that a low level of SorCS3 transcripts in low-grade glioma and high-grade glioma tissues was associated with shorter overall survival times in patients (Fig. 1A, B).