Next, we performed cell proliferation, invasion and migration assays in four glioma cell lines and patient-derived GBM cell lines after transfection with the pCMV3-SorCS3-Flag plasmid (Fig. 2A, C, F, I, Fig. S1B and Fig. S2A–C, Western blots were given in Original Data of Supplemental Material). Here, SORCS3 is linked to glioblastoma.