Including the covariates of tumor metaplasia, mitotic rate, and keratin 8 and/or 14 positivity (subsequent section), the HMMRTg/+ and HMMRTg/Tg effect estimates on Brca1-mutant tumorigenesis yielded similar results: HR = 2.32 (95% CI, 0.97–5.53; p = 0.058) and 4.46 (95% CI, 1.72–11.56; p = 0.002), respectively. The gene discussed is BRCA1; the disease is neoplasm.