MHC Class I Polypeptide-Related Sequence A/B (MICA/B) are ligands expressed on tumor cells for the NK-activating receptor NK group 2 member D (NKG2D)24; however, some tumors including leukemia, prostate cancer, melanoma, breast, lung, ovarian, and colon carcinomas frequently downregulate or shed these ligands to limit the cytotoxicity of NK cells5,25–27. Here, MICA is linked to neoplasm.