Mouse 4T1 cancer cells reprogrammed with SEVs passively transferred in transwell coculture system from Rab27a-depleted 4T1 cells infected with MRB∆G-amiR-4 (Fig. 4g) contained significantly less amiR-4 than cells exposed to the infected wild-type counterpart cells (P value = 0.0066) due to reduced SEV production in the Rab27a-depleted 4T1 cells (Fig. 4h). This evidence concerns the gene RAB27A and cancer.