CASP8 and omphalocele: In contrast, unlike Bax−/−;Bak−/−;Bok−/− foetuses, Bax−/−;Bak−/−;Bok−/−;Casp8−/−;Mlkl−/− foetuses did not show external facial clefts, exencephaly or omphalocele, although the differences in the incidence of these defects did not reach statistical significance at the number of animals available (Fig. 2c).