For example, Fgf21 KO-LP mice exhibit age-related weight loss earlier than any other group, several clinical markers of aging and frailty (alopecia, coat condition, kyphosis) were increased by LP in the Fgf21 KO mice, the subjective appearance of Fgf21 KO-LP mice declined earlier than any other group, Fgf21 KO-LP mice showed no improvement in rotarod performance, and finally grip strength was reduced. The gene discussed is FGF21; the disease is alopecia.