These reports are consistent with the results of this experiment, indicating that lncRNA-Gm31932 can participate in the regulation of B16 cell cycle arrest and differentiation by inhibiting the expression of Nuf2. Considering that reducing the expression of PRC1 and NUF2 can inhibit the proliferation of melanoma B16 cells, induce cell cycle arrest, and increase melanin content and tyrosinase activity. This evidence concerns the gene TYR and melanoma.