SLC6A3 and schizophrenia: While some genetic models have been developed in response to hypotheses of schizophrenia pathophysiology (e.g., dopamine transporter knockout or NMDA receptor NR1 subunit knockdown), others reflect findings from genetic studies of schizophrenia patients (e.g., DISC1, 22q11.2 deletion and NRG1 models) [46, 47].