Consistently, the promotion of OVM infection and amplification of ER stress proteins, such as pPERK (phospho–protein kinase RNA–like endoplasmic reticulum kinase), and pEIF2A (phospho–eukaryotic initiation factor 2a), on MXRA8 expressing tumor cells led to boosted OVM oncolysis, as the dose required to kill 50% of the cells (IC50) was sharply reduced in MXRA8-expressing cells (99-fold in HeLa, 413-fold in HT29, 700-fold in Hs578T and 4065-fold in HepG2 cells) (Fig. 2e, Supplementary Fig. 2f, g). This evidence concerns the gene MXRA8 and neoplasm.