MXRA8 and head and neck squamous cell carcinoma: Moreover, MXRA8 was significantly upregulated in head and neck squamous cell carcinoma (HNSC), lung adenocarcinoma (LUAD), kidney renal clear cell carcinoma (KIRC) and thyroid carcinoma (THCA) tissues compared with the corresponding normal tissues as evaluated by a paired t-test (Fig. 4b).