MAPT and Alzheimer disease: Typical pathology of hyperphosphorylated tau in neurons is primarily found in the neocortex (especially dorsolateral frontal cortex and superior temporal cortex), entorhinal cortex, amygdala, locus coeruleus, and hippocampus (especially subareas CA4 and CA2/3) [78, 79], which is associated with disease severity and aids in the differentiation from AD.